| SOUTHWEST REGION |
| Host - Kansas Christian College |
| Regional Twitter - @DII_Southwest |
| Regional Gear - shopnccaa.com |
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| TIME (CT) / GAME |
MATCHUP |
| Monday, February 21, 2022 |
| 5:00pm / Game 1 (at Barclay) |
#4N Barclay College def. #5N Spurgeon College 101-68 |
| Box Score |
| 6:30pm / Game 2 (at Dallas Christian) |
#4S Dallas Christian College def. #5S Randall University 87-82 |
| Box Score |
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| Wednesday, February 23, 2022 |
| 12:00pm / Game 3 |
#1S Arlington Baptist University def. #4N Barclay College 101-70 |
| Video | Box Score |
| 2:15pm / Game 4 |
#3S Southwestern Adventist University def. #2N Ozark Christian College 83-76 |
| Video | Box Score |
| 5:00pm / Game 5 |
#4S Dallas Christian College def. #1N Manhattan Christian College 91-87 OT |
| Video | Box Score |
| 7:15pm / Game 6 |
#3N Kansas Christian College def. #2S Champion Christian College 74-64 |
| Video | Box Score |
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| Friday, February 25, 2022 |
| 1:30pm / Semi 1 |
#1S Arlington Baptist University def. #3S Southwestern Adventist University 93-61 |
| Video | Box Score |
| 7:15pm / Semi 2 |
#3N Kansas Christian College def. #4S Dallas Christian College 70-64 |
| Video | Box Score |
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| Saturday, February 26, 2022 |
| 3:30pm / Championship |
#1S Arlington Baptist University def. #3N Kansas Christian College 79-75 |
| Video | Box Score |